Answers are grounded in this paper and cite their sources.
A knockout result: Fluorine substituents give drugs beneficial properties. By using a rational combination of genetic engineering and precursor-directed biosynthesis, fluorosalinosporamide (see scheme) was generated in a fermentation-based approach. The anticancer lead compound and marine natural product salinosporamide A is chlorinated. A comparison of the biological activity of these proteasome inhibitors is presented.
No takes yet. Share an insight, caveat, or question.
Eustáquio et al. (2008) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: