Synthesis of α-Cyclodextrin-Conjugated Poly(ɛ-lysine)s and Their Inclusion Complexation Behavior

Novel functional polymers utilizing specific host/guest interactions were designed by introducing α-CD host molecules into poly(ε-lysine) chains as side groups. An interesting phase separation was observed as a result of the inclusion complexation between the polymeric host and 3-(trimethylsilyl)propionic acid as a model guest in aqueous media. This water-soluble polymeric host would be useful for various applications, particularly drug delivery, due to its biodegradability, low toxicity, and unique functionality represented as a complexation-induced phase separation.