Key result
PIP5K2A rs8341 polymorphism links CT genotype to continuous and TT to episodic schizophrenia courses.
Why the study?
The role of protein kinases in schizophrenia is actively studied, but the effect of protein kinase gene polymorphisms on clinical manifestations of the disease has been little studied.
Are polymorphisms in neuronal protein kinase genes associated with the clinical course of schizophrenia?
Observational (n=384)
Are polymorphisms in neuronal protein kinase genes associated with the clinical course of schizophrenia?
The rs8341 polymorphism in the PIP5K2A gene is associated with the clinical course of schizophrenia, suggesting that phosphoinositide pathway disorders may contribute to a more severe continuous course.
rs8341 PIP5K2A CT genotype was associated with continuous schizophrenia course; leaves open genetic predictors of disease trajectory.
The role of protein kinases in schizophrenia is being actively studied. However, the effect of protein kinase gene polymorphisms on the clinical manifestations of the disease has been little studied. We examined 384 patients diagnosed with schizophrenia in accordance with ICD-10 (F20) (269 patients with a continuous course of schizophrenia; 115 patients with an episodic course of the disease). Genotyping of polymorphisms PIP5K2A (rs10828317, rs8341, rs746203), GSK3B (rs334558), AKT1 (rs3730358, rs1130214) was carried out by real-time PCR method. An association of rs8341 PIP5K2A with the type of course of schizophrenia was revealed. The CT genotype was associated with a continuous type of schizophrenia, the TT genotype with an episodic one. Disorders of the phosphoinositide pathway may be a possible cause of the transition to a more severe continuous course of schizophrenia.
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Poltavskaya et al. (2019) conducted an observational in Schizophrenia (n=384). PIP5K2A, GSK3B, and AKT1 gene polymorphisms vs. Alternative genotypes was evaluated on Type of course of schizophrenia (continuous vs episodic). The rs8341 PIP5K2A polymorphism was associated with the course of schizophrenia, with the CT genotype linked to a continuous course and the TT genotype to an episodic course.
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