Despite the lack of visceral involvement, localized scleroderma (LS) may be responsible for severe deformities and functional disabilities.1No drug has been proven to be effective in the treatment of LS.1-4In the present study, 17 patients with the most severe forms of LS were treated with oral corticosteroids in an open trial during a 10-year follow-up period in an attempt to assess the influence of oral corticosteroids on the course of LS. The inclusion criteria were the following: (1) the disease was severe and disabling and included facial scleroderma (en coup de sabre) in seven patients, linear scleroderma in five patients, and rapidly occurring generalized morpheas in five patients; (2) the diagnosis of scleroderma was established clinically and confirmed by skin biopsy specimen in 13 patients; (3) the absence of signs of progressive systemic scleroderma5 (in particular, no patient had visceral involvement); (4) treatment consisted of oral
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P. Joly (1994) studied this question.