Key result
Saphenous vein graft stenting is linked to a ~3-fold TNF-alpha increase that correlates with subsequent restenosis.
Why the study?
The relationship between TNF-alpha release during stent implantation in saphenous vein aortocoronary bypass grafts and its association with plaque extrusion and restenosis was unclear.
Does TNF-alpha release during stent implantation in saphenous vein grafts correlate with plaque volume reduction and restenosis in male patients with severe SVG stenosis?
Population
18 male patients with severe stenosis in saphenous vein aortocoronary bypass grafts (24 stents)
Comparison
TNF-alpha levels before vs after stent implantation
Design
Observational study using distal balloon occlusion-aspiration device during stent implantation
Follow-up
5 months
Authors
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Periprocedural TNF-alpha rise may flag restenosis risk after SVG stenting; hypothesis-generating and requires prospective validation before clinical use.
Observational (n=18)
Does TNF-alpha release during stent implantation in saphenous vein grafts correlate with plaque volume reduction and restenosis in male patients with severe SVG stenosis?
Absolute Event Rate: 28% vs 9%
p-value: p=<0.0001
Periprocedural release of TNF-alpha during saphenous vein graft stenting correlates with plaque volume reduction and predicts restenosis at 5 months.
Böse et al. (2007) conducted an observational in Severe stenosis in a saphenous vein aortocoronary bypass graft (SVG) (n=18). Stent implantation vs. Before stent implantation was evaluated on Aspirate TNF-alpha levels (pg/ml) (p=<0.0001). Stent implantation in saphenous vein grafts significantly increased aspirate TNF-alpha levels from 9 to 28 pg/ml (P<0.0001), which correlated with plaque volume reduction and 5-month restenosis.
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