Key result
Optimizing ovarian stimulation strategies is essential to prevent ovarian hyperstimulation syndrome during IVF.
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Design
Other
Natural cycle IVF may merit consideration in select cases; leaves open whether ovarian stimulation can be abandoned more broadly.
Given their enormous contributions to the field, the pioneers of in vitro fertilization (IVF) treatment—Jean Purdy, Robert Edwards, and Patrick Steptoe—may be excused for speculating in 1980 that ovarian stimulation may have to be “abandoned permanently in favour of monitoring the natural menstrual cycle” (1).
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Alexander Quaas (2025) studied this question. Optimizing habitual ovarian stimulation strategies is essential for the prevention of ovarian hyperstimulation syndrome during in vitro fertilization.
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