Lymphocyte Subpopulations in Sarcoid Pleural Effusion

Brief Reports1 January 1984Lymphocyte Subpopulations in Sarcoid Pleural EffusionGEORGE S. GROMAN, M.D., ROBERT J. CASTELE, M.D., MURRAY D. ALTOSE, M.D., JAMES SCILLIAN, Ph.D., MARY E. KLEINHENZ, M.D., ROLF EHLERS, M.D.GEORGE S. GROMAN, M.D., ROBERT J. CASTELE, M.D., MURRAY D. ALTOSE, M.D., JAMES SCILLIAN, Ph.D., MARY E. KLEINHENZ, M.D., ROLF EHLERS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-1-75 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSarcoidosis is a disease characterized by the formation on noncaseating granulomas in several organs of the body (1). Recent attention has been directed to the study of pulmonary lymphocyte populations and their function. Whether the changes in the type and function of T lymphocytes in sarcoidosis are confined only to the lung parenchyma or are also found in other sites of granuloma formation has not been established. We report lymphocyte subpopulations in the pleural fluid of a patient with sarcoidosis and pleural involvement.A 31-year-old woman had a 1-year history of progressive exertional dyspnea, dry cough, anosmia, intermittent right pleuritic...References1. DANIELE R, DAUBER J, and ROSSMAN M. Immunologic abnormalities in sarcoidosis. Ann Intern Med. 1980;92:406-16. LinkGoogle Scholar2. BOYUM A. Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest. 1968;21(suppl 97):77-89. MedlineGoogle Scholar3. GREAVES M and BROWN G. Purification of human T and B lymphocytes. J Immunol. 1974;112:420-3. CrossrefMedlineGoogle Scholar4. DAUBER J, ROSSMAN M, and DANIELE R. Bronchoalveolar cell populations in acute sarcoidosis: observations in smoking and non-smoking patients. J Lab Clin Med. 1979;94:862-71. MedlineGoogle Scholar5. HUNNINGHAKE G, FULMER J, YOUNG R, GADEK J, and CRYSTAL R. Localization of the immune response in sarcoidosis. Am Rev Respir Dis. 1979;120:49-57. MedlineGoogle Scholar6. GOLDHEIN P, BURTON R, HURWITZ C, KAZEMI H, and GINNS L. Identification of T-cell subsets in sarcoidosis by monoclonal antisera and flow cytometry [Abstract]. Am Rev Respir Dis. 1981;123:58. MedlineGoogle Scholar7. HUNNINGHAKE G and CRYSTAL R. Pulmonary sarcoidosis: a disorder mediated by excess helper T-lymphocyte activity at sites of disease activity. N Engl J Med. 1981;305:429-34. CrossrefMedlineGoogle Scholar8. HUNNINGHAKE G, GADEK J, YOUNG R, KAWANAMI O, FERRANS V, and CRYSTAL R. Maintenance of granuloma formation in pulmonary sarcoidosis by T-lymphocytes within the lung. N Engl J Med. 1980;302:594-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GEORGE S. GROMAN, M.D.; ROBERT J. CASTELE, M.D.; MURRAY D. ALTOSE, M.D.; JAMES SCILLIAN, Ph.D.; MARY E. KLEINHENZ, M.D.; ROLF EHLERS, M.D.Affiliations: Case Western Reserve University Cleveland, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySarcoidosisSystemic Diseases and the PleuraEnfermedades sistémicas y pleuraSeröse HöhlenPulmonary SarcoidosisPleural effusion in interstitial lung diseasePleural involvement in sarcoidosisSeröse HöhlenPleural, Alveolar and Blood T-lymphocyte Subsets in Pleuropulmonary SarcoidosisTuberculous pleural effusions: Lymphocyte phenotypes in comparison with other lymphocyte-rich effusionsDiagnostic differentiation between reactive and malignant lymphoid cells in serous effusionsImmunohistologic Identification of Antigen-Presenting Cells in Cutaneous SarcoidosisNeurosarcoidosis.Lymphocyte subpopulations in peripheral blood and malignant effusions of cancer patientsLymphocyte Subpopulations of Blood and Alveolar Lavage in BlastomycosisImmunocytochemical staining of T and B lymphocytes in serous effusions.Immunologic Diseases of the PleuraPleural Involvement in Sarcoidosis 1 January 1984Volume 100, Issue 1Page: 75-76KeywordsDyspneaGranulomasLungsLymphocytesPleural effusionPopulation statisticsSarcoidosis ePublished: 1 December 2008 Issue Published: 1 January 1984 PDF downloadLoading ...