Key result
Medical management successfully treated a newborn presenting with right upper limb brachial artery thrombosis caused by homozygous factor V Leiden and glycoprotein IIIa mutations.
Why the study?
Upper limb ischemia presenting in the neonatal period, especially due to intrauterine vascular occlusion, is extremely rare and requires prompt intervention to avoid morbidity.
Case Report (n=1)
Highlights the importance of investigating neonates and their parents for thrombophilia mutations when presenting with unusual vascular occlusion sites.
Raises awareness for inherited thrombophilia in neonates with congenital limb ischemia; leaves open the need for prospective studies on screening and therapy.
Upper limb ischemia presenting in neonatal period is extremely rare. Moreover, presenting newborn with evidence of intrauterine upper limb vascular occlusion is even rarer. It needs prompt intervention to restore perfusion and avoid morbidity. We present a newborn with right upper limb brachial artery thrombosis causing ischemia that was noted at birth and appeared later to be homozygous for factor V Leiden and glycoprotein IIIa with no other identifiable risk factors. In this report, we present the case, its successful medical management, proper counseling, and review of the literature. We recommend investigating the neonates and their parents for thrombophilia mutations when they present with unusual vascular occlusion site as newborns.
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Abdelrazeq et al. (2013) conducted a case report in Intrauterine upper limb ischemia (n=1). Medical management was evaluated on Clinical outcome. Medical management successfully treated a newborn presenting with right upper limb brachial artery thrombosis caused by homozygous factor V Leiden and glycoprotein IIIa mutations.
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