Key result
Bioelectronic medicine and neural reflex control emerge as potential therapies for vascular inflammation in CVD.
Why the study?
Inflammation plays a pivotal role in the development and progression of atherosclerosis, and new therapeutic strategies targeting vascular inflammation are being explored.
This review highlights the emerging concept of using bioelectronic medicine to target neural reflexes and modulate vascular inflammation in cardiovascular disease.
Answers are grounded in this paper and cite their sources.
Bioelectronic strategies targeting residual inflammation in atherosclerosis remain exploratory; leaves open any clinical role beyond current lipid and BP therapies.
Atherosclerosis is a multifactorial chronic inflammatory disease that underlies myocardial infarction and stroke. Efficacious treatment for hyperlipidemia and hypertension has significantly reduced morbidity and mortality in cardiovascular disease. However, atherosclerosis still confers a considerable risk of adverse cardiovascular events. In the current mechanistic understanding of the pathogenesis of atherosclerosis, inflammation is pivotal both in disease development and progression. Recent clinical data provided support for this notion and treatment targeting inflammation is currently being explored. Interestingly, neural reflexes regulate cytokine production and inflammation. Hence, new technology utilizing implantable devices to deliver electrical impulses to activate neural circuits are currently being investigated in treatment of inflammation. Hopefully, it may become possible to target vascular inflammation in cardiovascular disease using bioelectronic medicine. In this review, we discuss neural control of inflammation and the potential implications of new therapeutic strategies to treat cardiovascular disease.
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Caravaca et al. (2020) conducted a review in Atherosclerosis. Bioelectronic medicine was evaluated. Bioelectronic medicine and neural reflex control of inflammation represent potential new therapeutic strategies to target vascular inflammation in cardiovascular disease.
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