Objectives : Staphylococcus aureus is one of the leading causes of infectious diseases in humans. This study aimed to analyze the recent epidemiological trend of clones and genetic features of methicillin-resistant and susceptible S. aureus (MRSA/MSSA) isolates from children in Myanmar. Methods : S. aureus isolated from various specimens of pediatric patients were classified by genotyping schemes of MLST, coa, agr, spa , and SCC mec . Antimicrobial resistance genes were detected by uniplex/multiplex PCR, along with antimicrobial susceptibility testing by broth microdilution method. Results : A total of 175 S. aureus isolates (30 MRSA and 145 MSSA) and one S. argenteus were obtained during a 19 month-period (Sep. 2023 to Mar. 2025), with an MRSA rate of 17%. Panton-Valentine leukocidin (PVL) genes were detected at higher rate in MSSA (69%) than MRSA (43%). Among MRSA, CC1 (dominant types; ST772 and ST2885) was the major clonal group accounting for 47%, while other common clones were ST121 (CC121) and ST6 (CC5). The most dominant MSSA clone was ST121 (48%), including 86% of PVL-positive isolates, followed by ST88 (14%), and ST2990 (CC1) (9%). An S. argenteus was methicillin-susceptible and assigned as ST2250. In the present study, previously most common ST239 (CC8)-MRSA-III in 2017-2019 was not detected, whereas a growing prevalence was noted for CC1 and ST121 MRSA. Conclusions : The present study revealed the clonal structure of recent MRSA/MSSA isolates from pediatric patients and their potential changing trend in Myanmar.
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Aung et al. (2026) studied this question.
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