We evaluated the practicality of predicting phenytoin serum levels in an office practice. Once two phenytoin serum levels were obtained on two different dosage regimens, a table of future doses and predicted serum levels was calculated and plotted on a graph. Subsequent dosage adjustments resulted in serum levels that correlated well with predictions. In 7 of 10 patients, the predicted serum levels were within 2 pg per milliliter of the actual values. To improve compliance, the plot was used as a visual aid in patient education.
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Robson et al. (1993) studied this question.
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