Review: association between dna methylation of cyp gene family in vitamin d signalling pathway and type 2 diabetes

Diabetes is a major public health problem which occurs both due to environmental and genetic predisposition.The vitamin D deficiency is one of the factor causing type 2 diabetes and increasing its complications.Vitamin D regulates Ca 2+ in humans and CYP2R1 gene methylation decreases vitamin D level.Ca 2+ plays a pivotal role intracellular signal in the regulation of insulin secretion from pancreatic β-cells.So, deficiency of vitamin D due to CYP2R1 gene methylation affects Ca 2+ secretion which further affects insulin level.This fluctuation in insulin level due to CYP2R1 gene methylation might results in type 2 diabetes, although this statement needs further verification via experimental methods.