An oxime directed C–H activation–annulation reaction for the selective synthesis of a range of isoquinoline N -oxides has been developed. Under palladium-catalyzed acid-assisted conditions, the reaction undergoes concerted metallation deprotonation followed by carbopalladation and transmetallation to give polysubstituted isoquinoline N -oxides in moderate to good yields.
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Huang et al. (2013) studied this question.