Nanogap Field‐Effect Transistor Biosensors for Electrical Detection of Avian Influenza

A label-free biosensor based on a nanogap-embedded field-effect transistor is demonstrated. When biomolecules fill the molecular-sized nanogap, the transistor parameters are remarkably changed by the gate dielectric constant. The transistor detects specific binding between the avian influenza antibody and an antigen with the silica-binding protein.