March 26, 2015Synthesis

Iron-Catalyzed Oxidative C–C and C–O Coupling of Halophenols to α-Substituted β-Keto Esters

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Authors

DPDoron PappoBen-Gurion University of the Negev ARAlmog RegevBen-Gurion University of the Negev HSHadas ShalitBen-Gurion University of the Negev

Abstract

The iron-catalyzed oxidative cross-coupling of halophenols to α-substituted β-keto esters takes place through one of two modes: oxidative C–C coupling or oxidative C–O coupling. A mechanistic investigation revealed that the chemoselectivity of these reactions is determined by the electronic and steric properties of the two coupling partners.

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Cite This Study

Pappo et al. (2015) studied this question.

synapsesocial.com/papers/6aab84ca560fc25f005ec9dc https://doi.org/10.1055/s-0034-1380360

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