Bevacizumab-based therapy for advanced small bowel adenocarcinoma

We were most interested to read the recent report by Serviddio and colleagues ( Gut 2008; 57 :957–65). This work not only showed that upregulation of uncoupling protein-2 was a reason for progression of non-alcoholic steatohepatitis (NASH) from simple steatosis, but also gave an explanation for why NASH liver was especially vulnerable to ischaemia–reperfusion injury. NASH is a common liver disease that is estimated to affect nearly 1% of the population. A growing body of evidences shows that NASH …