Key result
Perilla ketone in ponies models restrictive lung disease driven by alveolar injury without airway obstruction.
Why the study?
Perilla ketone was assessed for its usefulness as a model of equine restrictive pulmonary disease.
Answers are grounded in this paper and cite their sources.
Offers a pony model of restrictive lung disease; leaves open translational value for respiratory research.
Perilla ketone was assessed for its usefulness as a model of equine restrictive pulmonary disease. Three ponies were given 18 mg/kg bodyweight synthetic perilla ketone in dimethyl-sulphoxide. Within 24 h of administration, respiratory rate, peak inspiratory and expiratory flow rates and minute volume were increased. By 48 h there was a significant decrease in tidal volume, and blood pH and base excess were also decreased but not outside normal limits. At necropsy there was congestion and oedema of the lungs. Histologically there was diffuse alveolar injury but no evidence of significant obstruction in bronchial or bronchiolar lumina. It is assumed that perilla ketone toxicity in ponies produces a restrictive disease without a significant obstructive component.
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Breeze et al. (1984) studied Equine restrictive pulmonary disease (n=3). Synthetic perilla ketone in dimethyl-sulphoxide was evaluated on Respiratory parameters and histological changes. Administration of 18 mg/kg perilla ketone in ponies produced a restrictive lung disease model characterized by diffuse alveolar injury and edema without significant airway obstruction.
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