Key result
Aslanger ECG pattern indicates severe multivessel CAD with acute occlusion requiring prompt reperfusion.
Why the study?
Current ACS categorization can lead to underrecognition of acute coronary occlusion, especially with atypical ECG findings such as the Aslanger pattern.
Case Report (n=2)
The Aslanger ECG pattern is a critical indicator of acute coronary occlusion and severe multivessel disease, requiring prompt recognition and intervention.
May prompt urgent angiography in suspected Aslanger pattern; leaves open prospective validation before practice change.
Current guidelines categorize acute coronary syndrome (ACS) into unstable angina, ST-segment elevation myocardial infarction (STEMI), and non-ST-segment elevation myocardial infarction (NSTEMI). However, this categorization paradigm can lead to the underrecognition of acute coronary occlusion (ACO), especially when electrocardiographic findings are atypical. The Aslanger pattern is a critical ECG signature characterized by isolated ST-segment elevation in lead III with concomitant ST depression in leads V4-V6. It is often associated with severe multivessel disease, poor prognosis, and high mortality. We present two cases of chest pain with ECGs consistent with the Aslanger pattern. Coronary angiography confirmed three-vessel disease, with ACO in at least one vessel and severe stenosis in another. Notably, Patient 1 suffered in-hospital mortality, while Patient 2 had an uneventful recovery, underscoring the impact of timely intervention. This report emphasizes the value of recognizing the Aslanger pattern to bridge a diagnostic gap in ACS, enabling early identification of ACO, prompt reperfusion therapy, and ultimately, improved patient outcomes.
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A 2025 study conducted a case report in Acute coronary syndrome (n=2). Aslanger ECG pattern was evaluated on Angiographic findings and clinical outcomes. The Aslanger ECG pattern indicated severe multivessel coronary artery disease with acute occlusion in two patients, underscoring its critical role in prompting early reperfusion therapy.
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