We retrospectively examined the effect of steroid treatment on the outcome of 458 consecutive patients admitted after out-of-hospital cardiac arrest. Of those given steroids, 128/213 (60%) regained consciousness, and of those not given steroids, 150/245 (61%) regained consciousness. Findings remained unchanged using logistic regression to adjust for differences in the two treatment groups. These results suggest that there is no role for steroids in the treatment of global brain ischemia.
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Grafton et al. (1988) studied this question.