All articles of this category Reaction of crotylindium sesquibromide with benzaldehyde in DMF at 20 °C affords syn -1-phenyl-2-methylbut-3-enol (ca. 40% de) after aqueous acidic work-up. At 22 °C in DMF, prior to work-up a greater relative proportion of the anti intermediate is decomposed as compared to its syn diastereomer. The resultant kinetic diastereoselection upgrades, the syn / anti ratio to 99/1 with a concomitant drop in overall yield. indium - allyl - kinetic diastereoselection - crotyl - aldehyde
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Lloyd‐Jones et al. (1998) studied this question.