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The preparation of the acetoxymethyl and pivaloyloxymethyl esters of cephaloglycin is described. These esters are well absorbed from the gastrointestinal tract and after the absorption are cleaved enzymatically with the liberation of cephaloglycin. As a result high blood- and tissue-levels of the latter are attained.
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Binderup et al. (1971) studied this question.
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