Key result
Oral pradigastat demonstrates complete absorption and very slow fecal elimination with negligible renal excretion.
Why the study?
The disposition of pradigastat in humans, including its absorption, metabolism, and excretion, was not fully understood.
Population
Healthy human subjects and familial chylomicronemia syndrome patients
Comparison
Oral and intravenous dosing of pradigastat
Design
In vivo absorption, metabolism, and excretion study plus intravenous pharmacokinetic and in vitro metabolism studies
Authors
Loading...
Characterizes pradigastat human disposition from in vitro data; leaves open clinical translation pending randomized trials.
Pradigastat exhibits complete oral absorption, slow metabolism to an acyl glucuronide, and slow fecal elimination with negligible renal clearance in humans.
Upthagrove et al. (2016) studied this question. Pradigastat was evaluated on Absorption, metabolism, and excretion. Pradigastat was completely absorbed after oral dosing and eliminated very slowly into the feces, with negligible renal excretion and minimal oxidative metabolism.
Synapse has enriched one closely related paper. Consider it for comparative context: