Key result
Thyroid extract in spontaneous myxedema is linked to increased cardiac output and reduced heart size.
Observational (n=5)
No
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Should not yet change practice in myxedema; leaves open confirmation of hemodynamic benefits in randomized trials.
Stewart et al. (1938) conducted an observational in Spontaneous myxedema (n=5). Thyroid extract vs. Baseline (pre-treatment) was evaluated on Circulatory function (cardiac output, arteriovenous oxygen difference, circulation time, heart size). Administration of thyroid extract to patients with spontaneous myxedema increased cardiac output, decreased arteriovenous oxygen difference, shortened circulation time, and reduced heart size.
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