The development and persistence of memory T cells are integral to effective host defenses. Cell metabolism has a central role in the maintenance of these populations and engagement of specific metabolic pathways can influence T-cell fate. Nuances in memory T-cell metabolism are both context dependent, and exist, on a spectrum that complements and supports the activity of specific memory T-cell subsets. This review explores how metabolic pathways and substrate choice can influence the phenotype and function of memory T cells.
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David O’Sullivan (2019) studied this question.
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