Key result
Serum ferritin levels were significantly correlated with the intensity of coronary artery stenosis across four angiographic scoring methods (e.g., Extent score R=0.26, p=0.001), whereas serum iron and transferrin saturation showed no significant relationship.
Why the study?
There are controversies regarding the impact of blood iron on myocardial infarction and coronary artery disease severity.
Does serum ferritin level correlate with the intensity of coronary artery stenosis in patients undergoing diagnostic coronary angiography?
Cross-Sectional (n=148)
Does serum ferritin level correlate with the intensity of coronary artery stenosis in patients undergoing diagnostic coronary angiography?
Serum ferritin levels, but not iron or transferrin saturation, are significantly correlated with the angiographic severity of coronary artery stenosis.
Answers are grounded in this paper and cite their sources.
Ferritin was associated with stenosis severity; leaves open causal role of iron reserves in CAD and need for prospective validation.
Various risk factors including blood iron may create coronary artery diseases and lead to myocardial infarction. There are controversies with regard to the impact of blood iron on myocardial infarction. Therefore, the aim of this paper was to investigate the relationship between iron reserves and the intensity of coronary artery stenos is among angiographic candidates in Zanjan, Iran. This was a cross sectional study. Samples were consisted of patients who were hospitalized for diagnostic coronary angiography in hospitals in an urban area of Iran. A convenient sampling method was used to recruit samples via interviews and laboratory examinations for FBS, iron, TIBC, ferritin, creatinine serum, CBC, cholesterol, HDL and LDL. The samples were divided into control and intervention groups. After coronary angiography, the intervention group was evaluated by four different methods including the extent score, stenos is score, vessel score and Duke CAN Index. The samples were consisted of 89 men (60.1%) and 59 women (39.9%). The levels of ferritin (p=0.003) and iron (p=0.002), and transferrin saturation percent (p=0.002) showed significant differences between males and females (p=0.004)
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Khalil Mahmoodi (2018) conducted a cross-sectional in Coronary artery disease (n=148). Serum ferritin levels was evaluated on Intensity of coronary artery stenosis (Extent score method) (R=0.26, p=0.001). Serum ferritin levels were significantly correlated with the intensity of coronary artery stenosis across four angiographic scoring methods (e.g., Extent score R=0.26, p=0.001), whereas serum iron and transferrin saturation showed no significant relationship.
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