Key result
Serum profiling reveals a ~50-fold increase in inflammatory marker haptoglobin in mdx-4cv mice versus wild-type.
Why the study?
It is unclear whether the pathological changes in skeletal muscle in Duchenne muscular dystrophy are reflected by altered protein release into the circulatory system or plasma fluctuations.
Population
mdx-4cv model of Duchenne muscular dystrophy
Comparison
Proteomic profile of mdx-4cv serum vs normal serum
Design
Label-free mass spectrometry proteomic analysis
Authors
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Hypothesis-generating in mdx models; human trials needed before any clinical translation.
Effect estimate: 50.3-fold increase
p-value: p=<0.05
Haptoglobin is identified as a highly elevated biomarker in the mdx-4cv model of Duchenne muscular dystrophy, potentially useful for evaluating inflammatory responses and monitoring therapy.
Murphy et al. (2017) studied Duchenne muscular dystrophy. mdx-4cv genotype (Dystrophin deficiency) vs. Wild-type C57BL6 mice was evaluated on Serum protein levels (specifically haptoglobin) (50.3-fold increase, p=<0.05). Proteomic profiling of mdx-4cv mouse serum revealed a 50.3-fold increase in the inflammation-induced plasma marker haptoglobin compared to wild-type mice.
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