PNA5, a glycosylated angiotensin-(1−7) mas receptor agonist for vascular dementia: A two species toxicology and toxicokinetic study

Figures

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  Fig. 1. PNA5 concentration curve in Sprague Dawley rat plasma. For all graphs, there are three injection concentrations: 1 mg/kg, 5 mg/kg, and 40 mg/kg; colors for the increasing concentrations are represented by an increase in color saturation. Injection concentrations on day 1 are represented by blue symbols and are designated the following colors: 1 mg/kg day 1 –light blue, 5 mg/kg day 1- royal blue, 40 mg/kg day 1- black blue. Injection concentrations on day 28 are represented by green symbols and are designated the following colors: 1 mg/kg day 1 –light green, 5 mg/kg day 1- leaf green, 40 mg/kg day 1- dark green. Plasma PNA5 concentration (pg/mL) in rats comparing Female vs Male for A) day 1 and B) day 28 are plotted against time (hours). Females are represented by filled circles, and males are represented by hollow circles. Combined sexes are represented by filled squares. Plasma PNA5 concentrations in rats (female and male values combined), comparing C) day 1 vs 28, are plotted against time. Significance between comparative groups at each time point was tested via a student's t-test. Significance is indicated via *. * p ≤ 0.05 **p ≤ 0.005. The Y axis is log-transformed.

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  Fig. 2. PNA5 concentration curve in Beagle dog plasma. For all graphs, there are three injection concentrations: 1 mg/kg, 5 mg/kg, and 20 mg/kg; colors for the increasing concentrations are represented by an increase in color saturation. Injection concentrations on day 1 are represented by blue symbols and are designated the following colors: 1 mg/kg day 1 –light blue, 5 mg/kg day 1- royal blue, 20 mg/kg day 1- black blue. Injection concentrations on day 28 are represented by green symbols and are designated the following colors: 1 mg/kg day 1 –light green, 5 mg/kg day 1- leaf green, 20 mg/kg day 1- dark green. Plasma PNA5 concentration (ng/mL) in dogs comparing female vs male for A) day 1 and B) day 28 are plotted against time (hours). Females are represented by filled circles, and males are represented by hollow circles. Combined sexes are represented by filled squares. Plasma PNA5concentrations in dogs (female and male values combined), comparing C) day 1 vs 28, are plotted against time. Significance between comparative groups at each time point was tested via a student's t-test. Significance is indicated via *. * p ≤ 0.05. The Y axis is log-transformed.