Key result
Ketogenic diet alleviates hypoglycemia-induced cognitive dysfunction and anxiety in mice by modulating gut microbiota.
Why the study?
Cognitive dysfunctions induced by hypoglycemia and their underlying mechanisms involving endoplasmic reticulum stress pathways require further investigation for potential therapeutic interventions.
Does a ketogenic diet alleviate cognitive dysfunctions induced by hypoglycemia in mice?
Does a ketogenic diet alleviate cognitive dysfunctions induced by hypoglycemia in mice?
A ketogenic diet may alleviate cognitive dysfunctions caused by hypoglycemia by modulating gut microbiota and suppressing endoplasmic reticulum stress pathways in a mouse model.
Does not support clinical use in hypoglycemia; leaves open gut microbiota–ER stress mechanisms for future translational research.
decreased in KD-fed mice. KD can not only alleviate anxiety-like behavior induced by hypoglycemia, but also increase the proportion of mushroom dendritic spines in the hippocampus by modulating changes in the gut microbiota. KD regulated synaptic plasticity by increasing the levels of SPN, PSD95, and SYP, which relieve cognitive impairment caused by hypoglycemia. Moreover, KD can promote the proliferation and survival of adult neural stem cells in the hippocampus, while reducing apoptosis by suppressing the activation of the IRE1-XBP1 and ATF6 endoplasmic reticulum stress pathways in mice with hypoglycemia. This study provides new evidence for demonstrating that KD may alleviate cognitive dysfunctions caused by hypoglycemia by modulating the gut microbiota.
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Li et al. (2023) studied Hypoglycemia-induced cognitive dysfunctions. Ketogenic diet was evaluated on Cognitive dysfunctions and anxiety-like behavior. Ketogenic diet alleviated cognitive dysfunctions and anxiety-like behavior induced by hypoglycemia in mice by modulating gut microbiota and suppressing endoplasmic reticulum stress pathways.
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