Key result
PON1 polymorphism and atherosclerosis severity show no association with cerebral amyloid angiopathy severity.
Why the study?
Both cerebral amyloid angiopathy and paraoxonase have been reported to be related to lipid metabolism and atherosclerosis, but their association with CAA risk is unclear.
Is the PON1 polymorphism or atherosclerosis associated with the severity of cerebral amyloid angiopathy in elderly individuals?
Observational (n=154)
Is the PON1 polymorphism or atherosclerosis associated with the severity of cerebral amyloid angiopathy in elderly individuals?
The PON1 polymorphism and atherosclerosis do not appear to be associated with the risk or severity of cerebral amyloid angiopathy in elderly Japanese individuals.
No association found; leaves open any role for PON1 or atherosclerosis in cerebral amyloid angiopathy pathogenesis and does not support clinical testing.
BACKGROUND AND PURPOSE: Both cerebral amyloid angiopathy (CAA) and paraoxonase have been reported to be related to lipid metabolism and atherosclerosis. We investigated whether the paraoxonase gene (PON1) polymorphism and atherosclerosis are associated with risk of CAA. METHODS: Associations of the PON1 polymorphism and atherosclerosis of the aorta and coronary and cerebral arteries with the severity of CAA were investigated in 154 elderly Japanese individuals, including 47 patients with Alzheimer's disease. RESULTS: The PON1 polymorphism or severity of atherosclerosis of the arteries was not associated with the severity of CAA. CONCLUSIONS: The PON1 polymorphism and atherosclerosis would not appear to be associated with risk of CAA in the elderly, although further study with larger samples is necessary for confirmation.
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Yamada et al. (2002) conducted an observational in Cerebral amyloid angiopathy (n=154). PON1 polymorphism and atherosclerosis was evaluated on Severity of cerebral amyloid angiopathy. The PON1 polymorphism and severity of atherosclerosis were not associated with the severity of cerebral amyloid angiopathy in elderly individuals.
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