Key result
Takayasu arteritis linked to ~2.1 m/s higher cfPWV versus controls, indicating impaired arterial stiffness.
Why the study?
Takayasu arteritis is strongly associated with increased cardiovascular risk, but its effect on arterial stiffness indices has been assessed in only a few studies.
Is Takayasu arteritis associated with increased arterial stiffness compared to controls?
Meta-Analysis (n=125)
Is Takayasu arteritis associated with increased arterial stiffness compared to controls?
Takayasu arteritis is associated with significantly increased arterial stiffness as measured by carotid femoral pulse wave velocity, suggesting a potential mechanism for increased cardiovascular risk.
Answers are grounded in this paper and cite their sources.
May warrant stiffness monitoring in Takayasu arteritis; leaves open prognostic value and intervention trials.
Introduction/Objective: Takayasu arteritis, a large vessel vasculitis, is strongly associated with increased risk for cardiovascular and chronic kidney disease.Arterial stiffness represents an established prognostic marker of cardiovascular disease development in the general population.A few studies have assessed the effect of Takayasu arteritis on arterial stiffness indices.Herein, we sought to provide pooled effect estimates regarding the impact of Takayasu arteritis on arterial stiffness, by retrieving relevant, available observational studies.Methods: On 1 st May, 2022, we searched two major electronic databases and grey literature sources for relevant observational studies.We set as primary outcome the mean difference in carotid femoral PWV (cfPWV) between patients with Takayasu arteritis compared to controls.Results: Regarding the primary outcome, we pooled data from 3 studies in a total of 125 enrolled subjects, demonstrating that Takayasu arteritis is associated with a significant increase in cfPWV by 2.06 m/s (MD = 2.06, 95% CI; 1.29 -2.83,I 2 = 0%, p < 0.001), compared to controls.Conclusion: The present preliminary meta-analysis demonstrates the potential deleterious effects of Takayasu arteritis on arterial stiffness.Prognostic implications must be confirmed in larger, prospective studies.
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Patoulias et al. (2022) conducted a meta-analysis in Takayasu arteritis (n=125). Takayasu arteritis vs. Healthy controls was evaluated on Mean difference in carotid femoral pulse wave velocity (cfPWV) (MD 2.06, 95% CI 1.29 - 2.83, p=<0.001). Takayasu arteritis is associated with a significant increase in carotid-femoral pulse wave velocity by 2.06 m/s compared to healthy controls, indicating impaired arterial stiffness.
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