Key result
Thrombolysis safely manages acute ischemic stroke in a pregnant woman with isolated LVNC.
Case Report (n=1)
This case report suggests that thrombolysis for acute ischaemic stroke can be safely administered during late pregnancy in selected patients with isolated left ventricular non-compaction.
Thrombolysis may be feasible in selected late-pregnancy ILVNC stroke; hypothesis-generating and should not yet change practice.
Isolated left ventricular non-compaction (ILVNC) is a rare congenital cardiomyopathy and is associated with arrhythmias, heart failure and thromboembolism including ischaemic stroke. Pregnancy is a relative contraindication to thrombolysis for acute ischaemic stroke, although case reports suggest the treatment can be given in selected cases. We report a case of recurrent cryptogenic strokes in a 36-year-old female who was thrombolysed with good outcome at 37 weeks' gestation and was eventually found to have ILVNC as the cause. She had a predilection to recurrent posterior circulatory strokes due to foetal posterior communicating arteries. To our knowledge this is the first case report of safe thrombolysis for acute ischaemic stroke in pregnancy caused by ILVNC.
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Juma et al. (2021) conducted a case report in Acute ischaemic stroke in pregnancy due to isolated left ventricular non-compaction (n=1). Thrombolysis was evaluated on Clinical outcome. Thrombolysis was safely administered with a good outcome for acute ischaemic stroke in a 36-year-old pregnant woman with isolated left ventricular non-compaction.
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