Key result
Elevated serum SOD during radiation therapy predicts radiation pneumonitis with ~80% sensitivity.
Why the study?
Serum superoxide dismutase (SOD) as a predictor for radiation pneumonitis in non-small cell lung cancer patients following chemoradiotherapy was not established.
Does serum superoxide dismutase predict radiation pneumonitis in non-small cell lung cancer patients following chemoradiotherapy?
Observational
Does serum superoxide dismutase predict radiation pneumonitis in non-small cell lung cancer patients following chemoradiotherapy?
Effect estimate: Sensitivity 0.80, Specificity 0.67
p-value: p=0.040
Serum superoxide dismutase measured during chemoradiotherapy may serve as a potential predictor for the development of radiation pneumonitis in patients with non-small cell lung cancer.
PURPOSE: To explore serum superoxide dismutase (SOD) for predicting radiation pneumonitis (RP) in non-small cell lung cancer patients following chemoradiotherapy. METHODS: Serum levels for SOD were measured by enzyme-linked immunosorbent assays prior to radiation therapy (Pre-RT) and post 40 Gy/4 weeks during the treatment (Pos-RT). RESULTS: SOD concentrations after delivery of 40 Gy/4 weeks was associated with the development of RP. The best predictive ability of SOD was observed for a cut-off value of 56 unit/ml, with a sensitivity of 0.80 (95% CI 0.28-0.99), and a specificity of 0.67 (95% CI 0.43-0.65) (p = 0.040). CONCLUSION: Serum SOD may be a potential predictor for RP, which need to be further verified.
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Wang et al. (2012) conducted an observational in Non-small cell lung cancer. Serum superoxide dismutase (SOD) was evaluated on Radiation pneumonitis (Sensitivity 0.80, Specificity 0.67, p=0.040). Serum superoxide dismutase levels >56 unit/ml after 40 Gy/4 weeks predicted radiation pneumonitis with a sensitivity of 0.80 and specificity of 0.67 (p=0.040).
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