STREPTOMYCETES tion, where two substances of low toxicity produce greater activity than can be accounted for from the additive effect.The antibiotic concentrations of 300 and 400 ,ug in combination with the cell concentrations within the limits of 5 X 105 to 20 X 105 per chick embryo were considerably more effective in potentiation of embryo death than were the 100 and 200 ug levels of antibiotic combined with cells of C. krusei.
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David Gottlieb (1961) studied this question.