The guanine‐nucleotide binding proteins EMBO‐NATO‐CEC advanced research workshop organized by L. Bosch, B. Kraal and A. Parmeggiani in Renesse, The Netherlands, August 6–11, 1988

Meeting report; Guanine-nucleotide binding proteinGuanine-nucleotide binding proteins are involved in a variety of diverse metabolic processes of central importance for prokaryotic and eukaryotic organisms.They serve as initiation and elongation factors in protein synthesis, they comprise a large family of regulatory proteins that mediate transmembrane signalling and presumably also are involved in regulating secretion and intracellular transport.Guanine-nucleotide binding proteins bind GTP as well as GDP with high affinity and have an intrinsic GTP hydrolysis activity.In general, the GTPase and the GDP/GTP-exchange reaction are subject to modulation by other proteins.Since GDP and GTP induce different conformations in their target proteins, guanine-nucleotide binding proteins cycle between two states of different ac-