The preparative enantiomer separation of the inhalation anesthetics enflurane (1), isoflurane (2) and, for the first time, desflurane (3) in high chemical and enantiomeric purity by preparative gas chromatography on octakis(3‐O‐butanoyl‐2,6‐di‐O‐pentyl)‐γ‐cyclodextrin (4) dissolved in SE‐54 and coated on Chromosorb P (AW‐DMCS) is described. Thermodynamic data for the observed enantioselectivities are reported. A discrepancy between the chiroptical and gas‐chromatographic assignment of the relative configuration of2and3is discussed. The1H‐ and19F‐NMR spectra of racemic1in the presence of4show good separation of the resonances of the enantiomers of1. Thermodynamic complexation constants derived from the1H‐NMR spectra of the complexes formed by4and the enantiomers of1were in good agreement with those obtained by GC.
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Schurig et al. (1995) studied this question.
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