Key result
Higher maximum radial wall strain is linked to ~56% higher risk of plaque rupture.
Why the study?
Radial wall strain is a potential marker of plaque vulnerability, but its association with plaque morphology in future ACS remains unclear.
Does radial wall strain derived from coronary angiography predict future plaque rupture or erosion in patients with acute coronary syndrome?
Cohort (n=98)
Yes
Does radial wall strain derived from coronary angiography predict future plaque rupture or erosion in patients with acute coronary syndrome?
Radial wall strain derived from a single angiographic projection can identify high-risk plaques prone to future rupture or erosion, offering a less invasive screening tool than intravascular imaging.
BACKGROUND: Radial wall strain (RWS) is a potential marker of plaque vulnerability; however, its association with plaque morphology in future acute coronary syndrome (ACS) remains unclear. METHODS AND RESULTS: spectrum. CONCLUSIONS: was independently associated with subsequent PR and PE, with a higher estimated probability of PR than of PE.
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Masuda et al. (2026) conducted a cohort in Acute Coronary Syndrome (n=98). Maximum radial wall strain (RWSmax) vs. Non-culprit lesions (NCLs) was evaluated on Subsequent plaque rupture (HR 1.56, 95% CI 1.34-1.82, p=<0.001). Higher maximum radial wall strain on prior coronary angiography was independently associated with subsequent plaque rupture (HR 1.56) and plaque erosion (HR 1.33) in patients with acute coronary syndrome.
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