Commentary highlights pulmonary epithelium-fibroblast interactions in systemic sclerosis, suggesting key cellular drivers behind progression to interstitial lung disease.
We have read with great interest the article by Rodríguez Viera and colleagues 1 employing a systematic review approach to identify soluble mediators in bronchoalveolar lavage fluid (BALF) that are differentially expressed between patients with systemic sclerosis (SSc)-associated interstitial lung disease (SSc-ILD) and those with SSc alone. The study underscores the central role of pulmonary epithelium–fibroblast interactions in driving the transition from SSc to SSc-ILD.
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Fang et al. (2026) studied this question.
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