Association of vitamin D receptor gene polymorphisms with risk of cutaneous melanoma. A meta-analysis based on 40 case-control studies

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Introduction.Previous studies on the association of vitamin D receptor (VDR) gene polymorphisms with cutaneous melanoma risk reported conflicting results.Objective.To obtain a more precise assessment of the associations, we performed a meta-analysis of previously published studies.Material and methods.We searched for eligible studies in the PubMed, Embase, and CNKI databases.A total of 40 case-control studies with 1,144 cases and 2,925 controls were included.Results.The pooled analyses suggested a significant association between the FokI C>T and BsmI G>A polymorphisms of the VDR gene and susceptibility to melanoma.However, we found that the VDR TaqI T>C, EcoRV A>G, ApaI G>T, and Cdx2 G>A polymorphisms were not associated with melanoma risk. Conclusions.The meta-analysis suggests that VDR FokI C>T and BsmI G>A polymorphisms are significantly associated with melanoma risk, while TaqI T>C, EcoRV A>G, ApaI G>T, and Cdx2 G>A polymorphisms are not associated with melanoma risk. StreSZcZeNieWprowadzenie.Dotychczasowe badania analizujące związek między polimorfizmami genu kodującego receptor witaminy D (VDR) a ryzykiem rozwoju czerniaka skóry przyniosły sprzeczne wyniki.Cel pracy.W celu uzyskania bardziej precyzyjnego obrazu tych zależności przeprowadzono metaanalizę opublikowanych do tej pory badań. Materiał i metody. Publikacje kwalifikujące się do metaanalizy wyszukano w bazach