Vitamin D Levels in Patients with Premature Ovarian Failure

Objective: To investigate the role of vitamin D in the pathogenesis of premature ovarian failure.Method: Forty-eight women diagnosed with POF, and 82 women recruited as controls were included in this crosssectional study, between January 2014 and April 2014, in a reference center of infertility in the capital of Turkey. 25(OH)D3 levels of the patients were determined with the use of a specific enzyme-linked immunosorbent assay kit.Results: There was no difference between two groups in terms of age, body mass index, smoking status, or sunlight exposure.25(OH)D3 levels did not differ between the POF group (7.75 [3-21.22]μg/L) and the control group (6.74 [3-25.54]μg/L) (P = 0.477).There was no significant correlation between vitamin D and follicle stimulating hormone levels or between vitamin D and estradiol levels. Conclusion:Although vitamin D level was reported to play a role in ovarian physiology, it seems not to have a role in the etiology of POF.Larger nation-wide or world-wide studies should be carried out to clarify the exact mechanism of POF.