Key result
Mannheim peritonitis index predicts mortality in perforative peritonitis with 100% sensitivity.
Why the study?
Successful management of peritonitis remains challenging despite medical and surgical advancements, motivating the development of severity grading systems to predict outcomes.
Does the Mannheim peritonitis index accurately predict mortality and morbidity in patients with perforative peritonitis?
Observational (n=100)
No
Does the Mannheim peritonitis index accurately predict mortality and morbidity in patients with perforative peritonitis?
The Mannheim peritonitis index is a highly sensitive and specific scoring system for predicting mortality and morbidity in patients with perforative peritonitis.
May support mortality risk stratification in perforative peritonitis; leaves open need for prospective validation.
Background: Successful management of peritonitis is a challenge to surgeons inspite of various advancements in medicine and surgical techniques. The outcome depends on various factors and early intervention. This led to the development of disease severity grading systems that would help grouping the patients by individual risk factors and appropriately predict possible outcome.Methods: The prospective study was conducted in the Department of General Surgery, Government Mohan Kumaramangalam Medical College Hospital, Salem. The study population included 100 patients presenting with perforative peritonitis in the emergency department. Preoperative data like age, gender, preoperative symptom duration and operative data like appearance of exudate, extent of exudates, source of sepsis where noted. Tissue biopsies were followed up. Duration of hospital stay and other postoperative complications were also noted. Patients were followed up till their discharge. The study end point was at patient’s discharge or death.Results: Among the patients who had the maximum score >29, 11% of the patients belonged to age group beyond 50 years. Mortality was 7%. The specificity and sensitivity of morbidity prediction was 89% and 88.9% respectively. The specificity and sensitivity of mortality prediction was 91.40% and 100% respectively. Mortality was highest in patients with score >29.Conclusions: Mannheim peritonitis index is a simplified scoring system with variables that can be assessed preoperatively, intraoperatively and postoperatively, to assess mortality and morbidity and instil appropriate treatment protocols which will bring out a positive outcome in the patients and increase survival rate.
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Mohan et al. (2019) conducted an observational in Perforative peritonitis (hollow viscous perforation) (n=100). Mannheim peritonitis index (MPI) vs. Lower MPI scores was evaluated on Mortality prediction (AUC 0.955, p=<0.001). The Mannheim peritonitis index accurately predicted mortality in patients with perforative peritonitis, yielding an area under the curve of 0.955 with 100% sensitivity and 91.4% specificity.
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