Teratogenic Effects of Combination Chemotherapy

Letters1 May 1974Teratogenic Effects of Combination ChemotherapyM. J. GARRETT, M.D., F.F.R.M. J. GARRETT, M.D., F.F.R.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-5-667_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Although thousands of patients have been treated by combination chemotherapy, little is known about its teratogenic effects. We report here the case of a patient and her foetus, in which combination chemotherapy was given in the first trimester of pregnancy.The patient was 27 years old when she was admitted for completion of a spontaneous abortion. The next month, in December 1971, she complained of sweating, loss of weight, and loss of energy. Her temperature was 38.5 °C, and a mass was found in the left iliac fossa. Biopsy confirmed the presence of Hodgkin's disease, shown to...References1. ARMSTRONGDYKEFOUTS JRP: Delivery of a normal infant during the course of oral vinblastine sulfate therapy for Hodgkin's disease. Ann Intern Med 61:106-115, 1964 LinkGoogle Scholar2. MYLES T: Hodgkin's disease and pregnancy. J Obstet Gynaecol Br Empire 62:884-891, 1965 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: M. J. GARRETT, M.D., F.F.R.Affiliations: Liverpool Regional Radiotherapy Centre Clatterbridge Hospital West Wirral, Cheshire L63 4JY England PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntineoplastic drugsCancer chemotherapeutic agents as human teratogensSpezielle Arzneimitteltherapie in der SchwangerschaftManagement of malignant gliomas during pregnancyAntineoplastic drugsMechlorethamineSpezielle Arzneimitteltherapie in der SchwangerschaftChemotherapeutic Drugs in PregnancyChemotherapy and PregnancyPrinciples of Teratogenesis Applicable to Drug and Chemical ExposureClinical teratology: identifying teratogenic risks in humansRADIATION THERAPY DURING PREGNANCYPharmacology of antineoplastic agents in pregnancyPregnancy, drugs, and the dermatologistImmunosuppressive Drug Therapy in Lupus NephritisBaseline and phosphoramide mustard-induced sister-chromatid exchanges in pharmacists handling anti-cancer drugsChemotherapy and pregnancyDermatologic drugs in pregnancyPregnancy and offspring after adjuvant chemotherapy in breast cancer patientsTreatment Options for Hodgkin's Disease During PregnancyMultiagent chemotherapy for sarcoma diagnosed during pregnancySpecies sensitivities and prediction of teratogenic potential.Late Effects of Treatment of Cancer in ChildrenCongenital PolyonychiasDrug Abuse in PregnancyLong Term Complications of TherapySuccessful pregnancy following continuous treatment with combination chemotherapy before conception and throughout pregnancyThe Normal and Pathologic NailCombination Chemotherapy During Early Pregnancy Causing Severe Intrauterine Growth Retardation and Congenital Malformations in the OffspringTeratogenic Risk AssessmentClinical aspects of developmental pharmacology and toxicologyComplications in the management of the malignant lymphomas (report no 15)Hereditary And Congenital States Associated With Nail ChangesAcute leukemia in pregnancy: Transient neonatal myelosuppression after combination chemotherapy in the motherOPERATIONS FOR DIVERTICULAR DISEASEACUTE LEUKÆMIA IN PREGNANCYNormal Infant after Treatment of Acute Myeloid Leukaemia in Pregnancy with DaunorubicinMultiple agent chemotherapy including bleomycin of non-hodgkin's lymphoma during pregnancyPREGNANCY AND LEUKÆMIATHE DOCTOR'S ROLE IN FERTILITY REGULATIONHydrazines and TriazenesTeratogenesis and ChemotherapyJOHN H. DI LIBERTI, M.D. 1 May 1974Volume 80, Issue 5Page: 667-667KeywordsBiopsyCombination chemotherapyHodgkin lymphomaMiscarriagePregnancyTemperatureWeight loss ePublished: 1 December 2008 Issue Published: 1 May 1974 PDF downloadLoading ...