Teratogenic effects of methamphetamine in mice and rabbits

Pregnant CFI mice and New Zealand White rabbits were given methamphetamine hydrochloride intravenously during days 9–15 and 12–30 of gestation, respectively. Offspring of mice given 5.0 mg/kg on days 9–15 of gestation had less than 2% anomalies. When 10.0 mg/kg were given on days 9–15, a 13.6% incidence of anomalies was observed. Offspring of rabbits receiving 1.5 mg/kg of methamphetamine on days 12–15, 15–20, and 12–30 of gestation showed an incidence of fetal anomalies of 12, 4, and 15.5% respectively. Offspring sired by treated males showed no significant weight change and had no increased anomaly rate.