Liquid-assisted grinding of an equimolar amount of pyrazinamide and p -nitrobenzoic acid yields two stoichiometric cocrystals in a 1:1 and 2:1 ratio, respectively. The 2:1 cocrystal was found to be the thermodynamically stable cocrystal based on solid stoichiometric interconversion, solvent-mediated conversion, and solubility studies.
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Abourahma et al. (2015) studied this question.
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