Key result
Blood pressure load indices, particularly the area of diastolic hypertension during sleep, strongly correlated with increased renal artery pulsatility index (R^2=0.80, p<0.001) in hypertensive patients.
Why the study?
The relationship between 24-h ambulatory blood pressure monitoring parameters and renal hemodynamics in hypertensive patients was unclear.
Do 24-h ambulatory blood pressure parameters correlate with renal hemodynamics in hypertensive patients?
Cross-Sectional (n=43)
No
Do 24-h ambulatory blood pressure parameters correlate with renal hemodynamics in hypertensive patients?
24-h ABPM parameters, specifically blood pressure load index, negatively impact renal pulsating index, suggesting utility in identifying hypertensive patients at high risk for renal injury.
The aim of the study was to assess relationship of results of 24-h ambulatory blood pressure (24-h ABPM) monitoring on the parameters of renal hemodynamic in hypertensive patients. The renal hemodynamic was evaluated by ultrasound Doppler. The glomerular filtration rate (on a clearance of endogenous creatinine) has been measured out before and after the acute oral protein loading for evaluation of renal functional reserve. The results of one-way ANOVA showed, that the «blood pressure load index» – areas under systolic and diastolic blood pressure curves and systolic and diastolic blood pressure-time index 24 h' influenced extremely negatively on renal pulsating index. These data and their values of 24-h ABPM may be useful for the clinical assessment of hypertensive patient by identifying those at high risk for the presence of renal injury.
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R. A. Sychov (2015) conducted a cross-sectional in Hypertension (n=43). High blood pressure load indices (time and area of hypertension) vs. Normal or lower blood pressure load indices was evaluated on Pulsatility index (PI) of segmental branches of renal arteries (Coefficient of determination (R^2) 0.80, p=<0.001). Blood pressure load indices, particularly the area of diastolic hypertension during sleep, strongly correlated with increased renal artery pulsatility index (R^2=0.80, p<0.001) in hypertensive patients.
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