Why the study?
Cholesterol microembolization syndrome as a complication of anticoagulant therapy is not well characterized in clinical practice.
Warfarin therapy can be associated with cholesterol microembolization syndrome, presenting as painful, purple-tinged toes.
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Clinicians should consider warfarin-related purple toe syndrome in elderly patients with painful discoloration; this Level 5 case leaves open incidence and causality.
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Varis et al. (2010) studied this question.
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