The distribution of co-ammo acid transaminases in microorganisms was investigated.co-Amino acid : pyruvate transaminase (co-APT) was found in bacteria and yeasts, but not in actinomycetes and fungi.On the contrary, aminobutyrate : a-ketoglutarate transaminase (GABA-T) was shown in most of the microorganisms from bacteria to fungi./?-Alanine is a preferred amino donor for the CO-APT reaction.Although bacterial and yeast GABA-T are inactive for /?-alanine, fungal and actinomycete enzymes react with this compound and y-aminobutyrate.In comparing these results with those of plant and mammalian enzymes, two different pathways of co-amino acid metabolism are suggested for bacteria, yeast and plants, i.e. one for /?-alanine and the other for yaminobutyrate, catalyzed by co-APT and GABA-T, respectively.In actinomycetes, fungi, and mammals GABA-T may be involved in the metabolism of both co-amino acids.In addition, evolutionary changes of co-amino acid transaminases are discussed.
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Yonaha et al. (1983) studied this question.