Key result
Chlorpromazine reversibly inhibits transient K+ currents in rat neurons, proving ~7 times more potent than 4-aminopyridine.
Why the study?
The differential blocking mechanisms of chlorpromazine and 4-aminopyridine on transient K+ currents in rat dorsal root ganglion neurones were not fully understood.
Population
Neurones of the newborn rat cultured dorsal root ganglia
Comparison
Chlorpromazine vs 4-aminopyridine vs control solution
Design
Preclinical whole cell patch-clamp electrophysiology study
Authors
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Chlorpromazine may probe transient K+ currents in sensory neurons; in vitro data leave open any clinical relevance or mechanism in humans.
Effect estimate: Kd 4.5 microM for CPZ vs 31 microM for 4-AP
Chlorpromazine preferentially blocks the transient K+ current in rat dorsal root ganglia neurones via a mechanism distinct from 4-aminopyridine.
Ogata et al. (1993) studied this question. Chlorpromazine and 4-aminopyridine vs. Control solution was evaluated on Inhibition of transient K+ current (IT) (Kd 4.5 microM for CPZ vs 31 microM for 4-AP). Chlorpromazine reversibly inhibited the transient K+ current in rat dorsal root ganglia neurones with a Kd of 4.5 microM, about seven times more potent than 4-aminopyridine (Kd 31 microM).
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