Key result
Lower resistin levels are unexpectedly linked to mortality and severe injury in multiply injured patients.
Why the study?
Resistin has been identified as a predictor of septic and SIRS events in neonatal and pediatric ICU patients but has not been studied in patients with multiple trauma despite its macrophage expression.
Can serum resistin levels predict trauma severity and clinical outcome in multiply injured patients?
Observational (n=12)
No
Can serum resistin levels predict trauma severity and clinical outcome in multiply injured patients?
p-value: p=<0.001
Unexpectedly low resistin levels may serve as an early biomarker for predicting severe trauma and mortality in multiply injured patients.
Should not yet inform trauma prognostication; leaves open resistin as a hypothesis-generating biomarker needing prospective validation.
Objective: Resistin plays a crucial role in the development of diabetes and several other internal diseases.Lately it was discovered as a predictor of septic and SIRS events in neonatal and paediatric ICU treatments as well.Regarding patients suffering a multiple trauma it was not considered yet even though it is expressed by macrophages and therefore might be one of the first proteins to be identified after a multiple trauma.Method: We used serum samples of patients with multiple trauma we collected and stored before.The patients were selected into three groups: ISS<25 for less severe traumatized patients, ISS>25 for severe traumatized patients and death during treatment. Results and Conclusion:With these samples we performed an ELISA to look for Resistin and IL-6.Resistin was highest in the ISS<25 group and slightly lower in the ISS>25 group with an increase in both.In the third group Resistin almost did not show any change in concentration.These findings show an unexpected result after performing an ANOVA test with statistically significant differences in the levels we measured but could as well lead to the goal of finding a new early marker for the severity of trauma and maybe an outcome parameter.
No takes yet. Share an insight, caveat, or question.
A 2022 study conducted an observational in Multiple trauma (n=12). Injury severity (ISS < 25, ISS > 25, non-survival) vs. Between-group comparison was evaluated on Mean resistin levels over the first 10 days after admission (p=<0.001). In multiply injured patients, resistin levels were unexpectedly lowest in non-survivors and highest in less severely injured patients (ISS < 25), showing significant differences between groups (p<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: