Are c-erb B2 and UGCG Reliable Immunohistochemical Markers Of Canine Mammary Carcinomas?

In this study, we aimed to correlate c-erb B2, UGCG expressions and tumor size in canine mammary tumors. The material of this study consisted of tissue samples of mammary carcinomas taken from ten female dogs brought to our department between 2012-2020. Avidin-Biotin Peroxidase method was used as an immunohistochemical method. All canine mammary tumor cases were immune positive for c-erb B2 and UGCG reactions. We detected membranous and cytoplasmic c-erb B2 immune positive staining in the neoplastic epithelial cells. Reactions were moderate to strong in severity. We observed strong dark brown cytoplasmic ceramide glucosyltransferase staining in the cytoplasm of neoplastic epithelial cells. We found that the increase in the number of c-erb B2 and UGCG immune positive cells paralleled the tumor size. In conclusion, the increase in the number of c-erb B2 and UGCG positive cells in direct proportion to the tumor size, which is an important diagnostic parameter in canine mammary tumors, made us think that c-erb B2 and UGCG could be reliable immunohistochemical markers in the diagnosis of canine mammary tumors. In addition, these markers must be evaluated comprehensively in line with different cancer diagnosis parameters.