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April 9, 2021Journal of the American Society for Mass SpectrometryOpen Access

High-Resolution Ion-Mobility-Enabled Peptide Mapping for High-Throughput Critical Quality Attribute Monitoring

James R. Arndt Kelly L. Wormwood Moser Gregory Van Aken Rory M. Doyle Tatjana Talamantes Daniel DeBord Laura Maxon George Stafford John C. Fjeldsted Bryan Miller Melissa Sherman

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Abstract

-extracted HRIM arrival time distributions, showing good agreement with the reference liquid-phase separation. This study shows, for the first time, the analytical capability of HRIM using SLIM technology for enhancing peptide mapping workflows relevant to biopharmaceutical characterization.

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Arndt et al. (2021) studied this question.

synapsesocial.com/papers/6aabd6b7e246da466683503f https://doi.org/10.1021/jasms.0c00434

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